UPREGULATION OF GLUTAMATE TRANSPORTER 1 BY CLAVULANIC ACID ADMINISTRATION AND ATTENUATION OF ALLODYNIA AND HYPERALGESIA IN NEUROPATHIC RATS

Upregulation of Glutamate Transporter 1 by Clavulanic Acid Administration and Attenuation of Allodynia and Hyperalgesia in Neuropathic Rats

Introduction: Clavulanic acid (CLAV) is structurally similar to ceftriaxone, a potent stimulator of glial GlutamateTransporter-1 (GLT-1) expression.The present study aims at exploring the anti-nociceptive effects of CLAV, a beta-lactamase inhibitor in rats underwent sciatic nerve Chronic Constriction Injury (CCI).Methods: CLAV (12.5, 25, 50 mg/kg)

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